gPROMS FormulatedProducts’s bioprocessing libraries provide sophisticated mechanistic models to facilitate workflows for design and optimisation of robust upstream and downstream steps such as bioreactors, fermentors, axial flow chromatography, simulated moving bed chromatography, membrane filtration and lyophilisation.
Advanced models, validated against process data, enable users to reduce experimentation and comprehensively explore the design space to ensure process robustness and optimise process performance whilst building an in-depth process understanding.
Validated models can be used for investigating batch vs continuous operation, process scale-up, and many other activities.
Bioreactors and fermentors
Design, explore, and optimise cell growth and production of the desired molecules of interest as a function of process operating decisions and biological variability in batch, fed-batch and continuous operational modes.
Optimally design and operate robust downstream purification processes with fewer resources, reduced risk and for better performance in both batch and continuous (simulated moving bed / periodic counter current) mode. Use the most appropriate model for the job, with a range of model complexities available to suit each project’s requirements.
Design membrane filtration processes and optimise operational and scheduling procedures, considering wide range of modes and configurations whilst minimising the impact of fouling.
Reduce experimentation and comprehensively explore the design space for freeze drying cycles with a view of ensuring process robustness. High – fidelity models allow for the transfer and optimisation of freeze drying processes between different equipment and scales while significantly reducing process downtime.